Why does prolactin level increase after taking bromocriptine?

Jul 13, 2022 Source: Cainiu Health

Dr. Pan Yongyuan

Introduction

After taking bromocriptine, prolactin levels paradoxically increased—this typically suggests that the administered dose is insufficient to achieve therapeutic effect. Prolactin is a polypeptide hormone, also known as lactogenic hormone or prolactin (PRL). In women, prolactin secretion markedly increases during late pregnancy and lactation to promote mammary gland development and milk production. In non-pregnant women, serum prolactin levels generally do not exceed 20 ng/mL.

If prolactin levels increase after taking bromocriptine, this is generally attributed to an insufficient dosage—not yet reaching the therapeutic threshold.

Prolactin is a polypeptide hormone—also known as lactogenic hormone—secreted by the anterior pituitary gland. During late pregnancy and lactation, prolactin secretion markedly increases to promote mammary gland development and milk production. In non-pregnant women, serum prolactin levels typically do not exceed 20 ng/mL.

Bromocriptine primarily acts by stimulating dopamine receptors, thereby inhibiting prolactin secretion. Some individuals exhibit heightened sensitivity to bromocriptine, while others may develop resistance to it. The time required for bromocriptine to lower prolactin levels varies significantly among individuals. Dose adjustment must therefore be guided by both clinical response and the physician’s experience.

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