Arteriosclerosis of the lower extremities in the elderly

Arteriosclerosis itself is a systemic disease that occurs more frequently in elderly individuals. It is a clear manifestation of arterial aging. As arteriosclerosis progresses, arterial stenosis—or even complete arterial occlusion—may develop. So, what about arteriosclerosis affecting the lower limbs in older adults?

Lower-Limb Arteriosclerosis in the Elderly

Lower-limb arteriosclerosis in the elderly represents a systemic, arteriosclerotic vascular disease affecting the arteries of the lower extremities. It is a chronic condition caused by atherosclerosis involving the lower-limb arteries, resulting in limb ischemia and consequent arterial stenosis or occlusion. Clinically, it commonly presents with symptoms such as coldness, numbness, weakness, and intermittent claudication in the lower limbs. In severe cases, it may lead to ischemic rest pain, ulcers, gangrene, and other related lower-limb manifestations.

In China, the prevalence of lower-limb arteriosclerosis obliterans (ASO) is approximately 10%. This rate increases with age, reaching 15–20% among individuals aged 70 years and older. The exact etiology of lower-limb ASO remains incompletely understood; however, it is generally believed that atherosclerosis development involves mechanisms such as endothelial injury, dyslipidemia, and hemodynamic alterations at arterial bifurcations, along with numerous other risk factors.

Patients are advised to undergo pharmacological treatment, including statins, lipid-lowering therapy, vasodilators, and antiplatelet agents. We hope this information proves helpful to you.