What causes high anti-TG levels?
Sep 08, 2022
Source: Cainiu Health
Dr. Pan Yongyuan
Introduction
The main causes of elevated thyroid globulin antibodies include subacute thyroiditis, Hashimoto's thyroiditis, and goiter. Subacute thyroiditis can trigger a hypersensitive response in the immune system, prompting the thyroid to produce large amounts of thyroid globulin antibodies to eliminate or suppress pathogen growth and replication. Hashimoto's thyroiditis stimulates the body to secrete excessive levels of thyroid globulin antibodies.
Anti-TG clinically refers to anti-thyroglobulin antibodies. Elevated levels of anti-thyroglobulin antibodies are mainly associated with subacute thyroiditis, Hashimoto's thyroiditis, and goiter.
1. Subacute Thyroiditis
Subacute thyroiditis is often related to bacterial or viral infections of the thyroid gland caused by harmful microorganisms. This can trigger a hypersensitive reaction in the immune system, prompting the thyroid to produce large amounts of anti-thyroglobulin antibodies to eliminate or suppress pathogen growth.
2. Hashimoto's Thyroiditis
Hashimoto's thyroiditis is an autoimmune disorder. The immune system causes the body to overproduce anti-thyroglobulin antibodies, which mistakenly attack the thyroid gland, resulting in persistently elevated levels of these antibodies in the blood.
3. Goiter
Goiter is a neoplastic thyroid condition. During rapid proliferation of hyperplastic tissue, normal thyroid tissue is repeatedly stimulated, leading to thyroid dysfunction. This results in a significant increase in serum anti-thyroglobulin antibody levels.
