What should not be taken with theophylline sustained-release tablets?
Sep 29, 2022
Source: Cainiu Health
Dr. Guo Xiheng
Introduction
Sustained-release theophylline tablets should not be taken concurrently with diltiazem, verapamil, cimetidine, antibiotics, phenobarbital, phenytoin, rifampicin, lithium salts, mexiletine, caffeine, or similar medications. Sustained-release theophylline tablets are indicated for relieving wheezing symptoms in bronchial asthma, asthmatic bronchitis, and obstructive pulmonary emphysema, and can also be used for asthma caused by cardiogenic pulmonary edema.
Theophylline sustained-release tablets are indicated for relieving symptoms of dyspnea in conditions such as bronchial asthma, asthmatic bronchitis, and obstructive pulmonary emphysema. They may also be used for asthma caused by cardiogenic pulmonary edema. However, this medication should not be taken with the following drugs:
1. Diltiazem and verapamil can interfere with the hepatic metabolism of theophylline. When used concomitantly, they increase the plasma concentration and toxicity of theophylline.
2. Cimetidine reduces the hepatic clearance of theophylline; co-administration may increase the serum concentration and (or) toxicity of theophylline.
3. Certain antibiotics, including macrolides (e.g., erythromycin, roxithromycin, clarithromycin), quinolones (e.g., enoxacin, ciprofloxacin, ofloxacin, levofloxacin), clindamycin, and lincomycin, can reduce theophylline clearance and elevate its plasma concentration, particularly erythromycin and enoxacin. Dosage reduction of theophylline is recommended when used with these agents.
4. Phenobarbital, phenytoin, and rifampicin induce liver enzymes and accelerate the hepatic clearance of theophylline. Theophylline may also interfere with phenytoin absorption, leading to reduced plasma concentrations of both drugs. Dosage adjustments are necessary when used together.
5. Concomitant use with lithium salts may increase renal excretion of lithium, thereby reducing its therapeutic effect.
6. Co-administration with mexiletine may decrease theophylline clearance and increase plasma theophylline levels, requiring dosage adjustment.
7. Concurrent use with caffeine or other xanthines may enhance their pharmacological effects and toxicity.
It is recommended that theophylline sustained-release tablets be taken under the guidance of a qualified physician.
