What does an elevated whole blood total C-reactive protein indicate?

Elevated levels of high-sensitivity C-reactive protein (hs-CRP) in whole blood generally indicate increased inflammatory markers in the body. This is commonly seen in normal physiological conditions, as well as in pathological factors such as bacterial infections, tissue necrosis, autoimmune diseases, and malignant tumors. Patients are advised to undergo timely re-examination and manage the condition according to their specific circumstances.

I. Physiological Causes:

After intense physical exercise, patients may experience elevated hs-CRP levels in whole blood. Additionally, pregnant women may also show increased inflammatory markers, which is considered a normal physiological phenomenon.

II. Pathological Causes:

1. Bacterial Infection: The presence of bacterial infection in the body can lead to elevated hs-CRP levels. C-reactive protein can bind to polysaccharide substances in bacteria, enhancing phagocytic activity.

2. Tissue Necrosis: Conditions such as acute myocardial infarction, severe burns, or trauma can result in localized tissue necrosis, leading to an increase in inflammatory cytokines and consequently elevated hs-CRP levels.

3. Autoimmune Diseases: Common conditions like rheumatoid arthritis and systemic lupus erythematosus involve immune system attacks on the body's own tissues, resulting in elevated inflammatory markers and thus increased hs-CRP levels.

4. Malignant Tumors: Cancers such as lung cancer and gastric cancer can destroy normal tissues, triggering inflammatory responses and causing elevated hs-CRP levels.