How much harm do white blood cell-increasing injections cause to the human body?

Granulocyte colony-stimulating factor (G-CSF) injection, also known medically as recombinant human granulocyte colony-stimulating factor injection, may cause certain harm to the digestive system, musculoskeletal system, and immune system when administered over a prolonged period.

1. Digestive System Effects

Administration of recombinant human granulocyte colony-stimulating factor injection may lead to loss of appetite and elevated levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), potentially resulting in liver-related disorders.

2. Musculoskeletal System Effects

Long-term use of this medication can stimulate the bone marrow, causing abnormally increased activity of hematopoietic cells, which may result in symptoms such as sternum pain, lower back pain, and muscle aches in patients.

3. Immune System Effects

This drug may also cause fatigue in bone marrow hematopoietic cells, thereby affecting and disrupting the immune system. After discontinuation of the drug, normal immune function may not be maintained. Reduced immunity increases susceptibility to various pathogens and may lead to a series of infectious diseases.

In addition to the above effects, some patients may experience headaches, fever, rashes, and fatigue. In rare cases, patients may develop interstitial pneumonia, shock, or adult respiratory distress syndrome.