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What does it mean when C-reactive protein and erythrocyte sedimentation rate are both elevated?

Nov 27, 2022 Source: Cainiu Health
Dr. Yang Shuwen
Introduction
Both C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are indicators of inflammation, reflecting the presence of inflammatory or infectious conditions. Elevated levels may result from inflammatory disorders, rheumatic autoimmune diseases, malignancies, and other causes, and treatment should be based on the specific underlying condition. Additionally, patients with respiratory tract infections or urinary tract infections may also exhibit increased CRP and ESR levels.

Both C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are indicators of inflammation, reflecting the presence of inflammatory or infectious conditions. They may be elevated due to inflammatory disorders, rheumatic autoimmune diseases, tumors, and other conditions.

1. Inflammatory Disorders

When inflammatory conditions such as tonsillitis or bronchitis occur, inflammatory stimuli can lead to an accelerated ESR. As a result, CRP levels significantly increase, causing both elevated ESR and high CRP. Treatment with anti-inflammatory medications under a doctor's guidance is recommended.

2. Rheumatic Autoimmune Diseases

Rheumatoid arthritis, systemic lupus erythematosus, and dermatomyositis are all classified as rheumatic autoimmune diseases. During active phases, inflammatory stimuli cause increased levels of CRP in the blood. Regular, moderate physical exercise may help alleviate symptoms.

3. Tumor Diseases

In cancer patients, malignant cells can damage body tissues and organs, and often lead to elevated CRP levels in the blood. It is important to actively follow medical treatment plans to prevent disease progression.

In addition, patients with respiratory tract infections or urinary tract infections may also exhibit elevated CRP and ESR levels.

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