Uric acid levels rebound as soon as benzbromarone is discontinued.

Uric acid levels may rebound after discontinuing benzbromarone, possibly due to premature cessation of medication, dietary factors, underlying medical conditions, and other reasons.

1. Premature Discontinuation

Benzbromarone tablets are primarily used to treat hyperuricemia and joint pain caused by gout, and they work by promoting uric acid excretion. In cases of severe disease, if the condition has not been adequately controlled and the medication is stopped prematurely, uric acid levels may continue to rise, leading to a rebound in uric acid after stopping the drug.

2. Dietary Factors

After discontinuing the medication, failure to maintain a healthy lifestyle—particularly continued consumption of high-purine foods such as animal organs, beef, and mutton—can lead to excessive production of uric acid in the body, resulting in a rebound of uric acid levels following cessation of benzbromarone.

3. Underlying Medical Conditions

In patients with conditions such as nephrotic syndrome or chronic nephritis, kidney excretory function may be impaired. If these underlying diseases are not effectively managed, uric acid cannot be properly excreted and accumulates in the body, causing a rebound in uric acid levels after stopping benzbromarone.

Additionally, a purine metabolism disorder may also contribute, leading to uric acid accumulation—a condition also known as metabolic arthritis. Regarding diet, it is important to eat light meals and avoid high-purine foods such as red meat, beer, and seafood. Drinking plenty of water is recommended to help promote uric acid excretion.