Why are the reference values for uric acid different between males and females?

The reference values for uric acid differ between men and women due to differences in body structure.

Uric acid levels are influenced by multiple factors, including age, diet, physical activity, lifestyle habits, and diseases. The primary reason for different reference ranges between men and women lies in their distinct physiological structures. Normally, the reference range for uric acid in men is 150–416 μmol/L, while for women it is 89–357 μmol/L. Results within these ranges are considered normal. Values below or above the reference range may indicate an abnormal condition.

Elevated uric acid levels may result from consuming large amounts of high-purine foods, or could be caused by medical conditions such as gout or nephritis. Low uric acid levels might stem from physiological or medication-related factors, or potentially from liver necrosis. If abnormal uric acid levels are detected, it is advisable to seek medical evaluation promptly to rule out underlying diseases. In daily life, one should develop healthy eating habits, maintain regular meal times, and avoid overeating.