The key to effective treatment of uncomplicated acute pyelonephritis is completing several days of therapy.

The key to effective treatment of uncomplicated acute pyelonephritis is generally completing a 14-day course of therapy.

Uncomplicated acute pyelonephritis refers to an acute inflammatory condition caused by bacterial invasion of the renal pelvis, affecting one or both sides, and is a type of urinary tract infection. This condition is more commonly seen in women, as physiological factors make women significantly more susceptible to urinary tract infections than men, especially during menstruation, pregnancy, and menopause, which are high-risk periods.

Most patients with pyelonephritis have mild, uncomplicated acute pyelonephritis, typically presenting symptoms such as chills and high fever. The cornerstone of treatment is antibiotic therapy for infection control. Under medical guidance, patients may take medications such as cefradine capsules or cefuroxime axetil capsules, with a typical treatment duration of 10–14 days. If a patient experiences significant flank pain or gross hematuria, appropriate bed rest is recommended, avoiding strenuous activities to prevent disease fluctuations. As the condition improves, light physical activities such as walking or jogging can be resumed.

Patients should maintain good personal hygiene, particularly ensuring cleanliness of the perineal area, and frequently changing undergarments.