How high does the bilirubin level need to be to affect the brain?

A bilirubin level typically above 17.1 µmol/L may affect the brain.

Jaundice results from impaired bilirubin metabolism, leading to elevated serum bilirubin levels. It commonly causes yellowing of the sclera, mucous membranes, skin, and other tissues. When bilirubin levels exceed 17.1 µmol/L, caution is required, as bilirubin can cross the blood-brain barrier and bind to neural tissue, potentially causing brain damage and symptoms such as lethargy. In severe cases, it may lead to cerebral palsy.

When jaundice occurs, appropriate measures should be taken. Medications such as anti-inflammatory and bile-promoting tablets or Yinzhihuang oral liquid may be used under medical guidance. Additionally, drinking plenty of water can promote metabolism and accelerate the elimination of bilirubin from the body.