Can you get liver cancer if alpha-fetoprotein (AFP) levels are low?

Low levels of alpha-fetoprotein (AFP) generally indicate a low risk of liver cancer, but patients are still advised to follow medical instructions for treatment.

Liver cancer is a malignant tumor originating in the liver and may be caused by factors such as viral hepatitis, aflatoxin exposure, or liver fibrosis. Patients may experience symptoms including liver area pain, decreased appetite, abdominal bloating, nausea, and vomiting. Alpha-fetoprotein is a glycoprotein synthesized by fetal liver cells and the yolk sac. It is normally present at high concentrations in fetal circulation but gradually declines after birth, being largely replaced by albumin. Therefore, most adults have low serum AFP levels and do not develop liver cancer. Clinically, AFP is closely associated with the development of liver cancer. Elevated AFP levels are often found in the serum of patients with various tumors, and AFP measurements are commonly used to diagnose primary liver cancer or monitor treatment response.

Low AFP levels are typically normal. If no other abnormalities or discomfort are present, it is recommended to follow medical advice for regular follow-up examinations and maintain healthy lifestyle habits.