Can MDS relapse 4 years after transplantation still be treated?
Mar 28, 2023
Source: Cainiu Health
Dr. Zhang Heyang
Introduction
For MDS patients who experience relapse four years after transplantation, treatment options generally include medications, radiation therapy, and a second bone marrow transplant. MDS is a malignant disorder caused by abnormal clonal proliferation of hematopoietic stem cells in the bone marrow, leading to ineffective hematopoiesis and impaired blood cell production. Additionally, after treatment, patients should take prescribed medications regularly under a doctor's guidance to reduce the risk of graft rejection.
In general, myelodysplastic syndrome (MDS) that recurs four years after transplantation can still be treated. The specific analysis is as follows:
MDS is a malignant disease caused by abnormal clonal proliferation of hematopoietic stem cells in the bone marrow, leading to ineffective hematopoiesis and impaired blood cell production. Recurrence after transplantation can usually still be managed. Under a doctor’s guidance, medications such as thalidomide tablets or decitabine tablets may be used for treatment. If MDS recurs, it may lead to bone marrow failure, which can be treated with chemotherapy at a hospital. The response rate of chemotherapy for MDS can reach 60%–70%, although the actual effectiveness depends on individual circumstances. A recurrence of MDS indicates disease progression, and in such cases, a second allogeneic hematopoietic stem cell transplant may be considered under medical supervision.
Besides, after treatment, patients should continue taking prescribed medications as directed by their doctors to help reduce the risk of graft rejection.
