Bleeding from the injection site several hours after administering heparin

Generally, persistent bleeding at the injection site after heparin administration may be caused by incorrect pressure application, excessive heparin dosage, or use of protamine sulfate injection. Treatment options include applying proper pressure, adjusting the heparin dose, or using protamine sulfate injection.

1. Pressure Application

If the injection site is not properly pressed or if pressure is applied for an insufficient duration after heparin injection, mild bleeding may occur. After injecting heparin, press the site for 15–20 minutes. Under medical guidance, patients may also take oral vitamin C tablets to help alleviate symptoms.

2. Adjusting Heparin Dosage

Some patients with inherited coagulation disorders may experience severe bleeding following minor injuries or surgeries, including prolonged bleeding from injection sites, tooth extractions, or minor procedures. Patients can, under a doctor’s supervision, appropriately reduce their heparin dosage to relieve persistent bleeding at the injection site.

3. Protamine Sulfate Injection

Heparin has anticoagulant effects; when administered in excess, it may lead to spontaneous bleeding, often accompanied by bleeding after injection. To neutralize heparin's effects and control bleeding at the injection site, patients may receive slow intravenous injections of protamine sulfate under medical supervision.

In addition, supplementing clotting factors may also help relieve the above symptoms. Patients are advised to seek timely medical evaluation to determine the underlying cause and receive appropriate treatment.