What causes low glutamate aminotransferase?

Under normal circumstances, low levels of glutamyl aminotransferase may result from normal physiological phenomena, or could be caused by the acute phase of hepatitis B or severe hepatitis. The specific analysis is as follows:

1. Normal physiological phenomenon

Glutamyl aminotransferase is mainly present in the liver, kidneys, and pancreas. The glutamyl aminotransferase found in serum primarily originates from the hepatic and biliary systems. The normal reference range for glutamyl aminotransferase is 0–40 IU/L; values at the lower end of this range are considered normal.

2. Acute phase of hepatitis B

During the acute phase of hepatitis B, inflammation and necrosis of hepatocytes occur, leading to loss of normal function in most liver cells, including their ability to produce glutamyl aminotransferase, thus resulting in decreased enzyme levels.

3. Severe hepatitis

In patients with severe hepatitis, extensive hepatocyte necrosis prevents the body from synthesizing sufficient glutamyl aminotransferase, leading to reduced enzyme levels.

In addition, bile duct obstruction could also be a contributing factor. When low glutamyl aminotransferase levels are detected, further examinations such as liver function tests and color ultrasound should be performed. Only after a comprehensive evaluation can appropriate treatment measures be determined.