What does "live hepatitis A vaccine" mean?
Apr 12, 2023
Source: Cainiu Health
Dr. Jiang Weimin
Introduction
The live hepatitis A vaccine is a type of vaccine that prevents hepatitis A. It contains live virus capable of triggering an immune response, thereby enabling the body to develop protection against the hepatitis A virus. Common types of live hepatitis A vaccines include human immunoglobulin hepatitis A vaccine and lyophilized hepatitis A vaccine. Besides the live vaccine, there is also an inactivated vaccine, which lacks reproductive ability and infectivity.
Hepatitis A live vaccine is a type of vaccine that prevents hepatitis A. It contains live attenuated virus capable of stimulating an immune response, prompting the body to develop protection against the hepatitis A virus. Common types of hepatitis A live vaccines include human immunoglobulin hepatitis A vaccine and freeze-dried hepatitis A vaccine.
1. Human Immunoglobulin Hepatitis A Vaccine
The human immunoglobulin hepatitis A vaccine typically refers to hepatitis A virus immunoglobulin, an antibody product prepared from human serum specifically targeting the hepatitis A virus. It is used to prevent hepatitis A virus infection and provides immediate immune protection after exposure to the virus. It is suitable for susceptible populations requiring preventive vaccination, such as travelers visiting endemic areas, individuals visiting friends or relatives in high-risk regions, and professionals working in food service, healthcare, and marriage-related services.
2. Freeze-Dried Hepatitis A Vaccine
The freeze-dried hepatitis A vaccine is manufactured through processing of hepatitis B surface antigen and contains active HBsAg antigen in lyophilized form, providing immune protection against hepatitis A. This vaccine must be stored at low temperatures between 2–8°C and needs to be reconstituted with diluent before being administered via intramuscular injection. It is widely used among populations requiring regular vaccination, such as healthcare workers and certain high-risk groups.
In addition to the live hepatitis A vaccine, there is also an inactivated version, which lacks reproductive ability and is non-infectious. The inactivated vaccine requires two doses administered six months apart.
