How to determine the severity of a disulfiram-like reaction
Apr 16, 2023
Source: Cainiu Health
Dr. Yang Shuwen
Introduction
The severity of a disulfiram-like reaction depends on the amount of medication taken and alcohol consumed. If the medication dose and alcohol intake are both low, mild disulfiram-like reactions such as dizziness or headache may occur; these are generally not serious and can improve with increased water intake to enhance metabolism. However, if large amounts of medication and alcohol are consumed, severe disulfiram-like reactions such as palpitations and shortness of breath may develop, which are more serious and require prompt medical attention.
Generally, the severity of a disulfiram-like reaction depends on the dosage of medication taken and the amount of alcohol consumed. The specific analysis is as follows:
1. Mild cases
A disulfiram-like reaction, also known as "alcohol flush reaction," occurs when disulfiram inhibits aldehyde dehydrogenase in the body, disrupting the normal metabolism of ethanol. If the medication dose is low and only a small amount of alcohol is consumed, mild disulfiram-like symptoms may occur, such as dizziness, headache, nausea, or vomiting. These cases are generally not severe. Adequate rest and increased fluid intake can promote metabolism and help alleviate symptoms.
2. Severe cases
If a large dose of medication is taken along with significant alcohol consumption, a severe disulfiram-like reaction may develop. Symptoms may include facial flushing, palpitations, shortness of breath, weakness in limbs, and even hypotension or respiratory distress. Such cases are usually serious and require immediate medical treatment to prevent life-threatening complications.
In daily life, it is important to maintain a balanced diet, engage in regular physical activity, and avoid alcohol consumption during medication to prevent adverse effects on health.
