Papaverine Hydrochloride for Injection: Mechanism of Action and Efficacy
Apr 21, 2023
Source: Cainiu Health
Dr. Wang Lei
Introduction
Papaverine hydrochloride for injection has pharmacological effects and indications including coronary artery dilation, blood pressure reduction, improvement of myocardial metabolism, anti-arrhythmia, and treatment of pulmonary hypertension. In addition, it is also used for anti-arrhythmic purposes and the management of pulmonary arterial hypertension. This medication must be prescribed and administered under a physician's diagnosis. It should be used strictly according to medical instructions; patients must not adjust the dosage or alter the route of administration without authorization.
Under normal circumstances, the effects and functions of papaverine hydrochloride for injection mainly include coronary artery dilation, blood pressure reduction, and improvement of myocardial metabolism. The specific analysis is as follows:
1. Coronary Artery Dilation
As a KATP channel opener, it can relax vascular smooth muscle, especially that of the coronary arteries, thereby dilating the coronary arteries, increasing blood supply to the heart, and relieving angina pectoris.
2. Blood Pressure Reduction
It can dilate blood vessels and reduce peripheral vascular resistance. Additionally, papaverine hydrochloride can decrease sympathetic nervous system activity, lowering heart rate and cardiac output, thus reducing blood pressure.
3. Improvement of Myocardial Metabolism
By dilating the coronary arteries and improving the metabolic state of myocardial tissue, it enhances the efficiency of oxygen utilization in the myocardium, thereby alleviating myocardial hypoxia. Furthermore, papaverine hydrochloride can increase ATP levels in the myocardium, promoting recovery of myocardial metabolism.
In addition, it has other effects such as antiarrhythmic action and treatment of pulmonary arterial hypertension. It must be used only under medical diagnosis and prescription. Patients should strictly follow medical instructions and must not adjust dosage or change administration methods on their own.
