How long does it take for 30% acetic acid solution to show effect when applied for treating toenail fungus?

It usually takes about three months of treatment with 30% glacial acetic acid solution before noticeable improvement can be seen in treating onychomycosis (fungal nail infection). Details are as follows:

Onychomycosis is a common condition caused by fungal infection, primarily characterized by thickened, deformed nails, discoloration (often turning grayish or dull), and even nail detachment. There are various treatment methods available for onychomycosis, among which topical application of 30% glacial acetic acid solution is a commonly used approach—though the required treatment duration may vary depending on individual circumstances. Glacial acetic acid is an organic acid that can kill the fungi responsible for onychomycosis and inhibit their growth and reproduction. A concentration of approximately 30% acetic acid is typically used for this purpose. The treatment involves applying the 30% glacial acetic acid solution evenly to the affected area once daily, continuing for 4 to 6 months. The exact duration may vary from person to person. Generally, mild cases of onychomycosis may show improvement after 1–3 months of topical treatment with 30% glacial acetic acid. Moderate to severe cases, however, often require longer treatment periods. It is important to use the solution consistently throughout the treatment course and avoid stopping prematurely, to prevent recurrence of the infection.

In addition to using 30% glacial acetic acid topically, other treatment options include oral antifungal medications and topical antifungal agents. When selecting a treatment method, individuals should consider their specific condition and the severity of the infection, and treatment should always be conducted under medical supervision. Additionally, during treatment, it is essential to maintain proper foot hygiene, avoid damp environments, and minimize the risk of worsening the condition or spreading the infection to others.