What are the characteristics of C-peptide in type 2 diabetes?
Apr 29, 2023
Source: Cainiu Health
Dr. Pan Yongyuan
Introduction
In type 2 diabetes, C-peptide levels are typically normal or slightly elevated in the early stage, but may decline in the later stages. Insulin and C-peptide are secreted in equimolar amounts; that is, when one molecule of proinsulin is processed to release one molecule of insulin, an equivalent molecule of C-peptide is also released. Therefore, in the early phase of type 2 diabetes, C-peptide levels may be normal or elevated, while a decrease may occur in the advanced stages.
In type 2 diabetes, C-peptide levels are typically normal or elevated in the early stages, but may decline in the later stages. The details are as follows:
Type 2 diabetes is primarily caused by genetic and environmental factors, with obesity being a major contributing factor. During the development of obesity, insulin resistance commonly occurs, leading to hyperinsulinemia. Insulin and C-peptide are secreted in equimolar amounts from the body—when one molecule of insulin is released from proinsulin, one molecule of C-peptide is also released. Therefore, hyperinsulinemia often results in elevated C-peptide levels. Consequently, in the early stages of type 2 diabetes, C-peptide levels are usually normal or increased. However, in advanced stages of type 2 diabetes, patients' pancreatic beta cells gradually deteriorate, causing insulin levels in the body to progressively decrease, which may lead to reduced C-peptide levels.
Patients are advised to seek timely medical attention when experiencing discomfort and to receive standardized treatment under a doctor's guidance, which helps promote recovery.
