What is leukemia-like disease?

May 05, 2023 Source: Cainiu Health
Dr. Zhang Heyang
Introduction
Leukemia-like disease is a malignant tumor caused by leukemic clone cells invading the bone marrow and peripheral blood system. Malignant transformation of hematopoietic stem cells and precursor cells leads to hematopoietic dysfunction and related symptoms. Chemotherapy is the primary treatment approach, with drugs such as fludarabine phosphate injection being commonly used. Leukemic cells occupy space and consume nutrients normally required by healthy tissues, and the release of large numbers of leukemic cells exacerbates the patient's condition.

Leukemia is a type of malignant tumor. The specific details are as follows:

Leukemic clone cells derived from hematopoietic stem cells or precursor cells infiltrate the bone marrow and peripheral blood system, leading to suppression and dysregulation of blood and bone marrow production, thereby causing leukemia. Abnormalities occur during the normal differentiation process of hematopoietic cells into mature cells, resulting in malignant transformation of stem cells or precursor cells. These transformed cells lose normal regulatory mechanisms and exhibit characteristics of uncontrolled proliferation and impaired differentiation. Leukemic stem cells disrupt the production of normal hematopoietic cells, occupying space and nutrients within normal hematopoietic tissues, which leads to symptoms such as bone marrow failure and anemia. Chemotherapy is currently the primary treatment approach. It involves using chemotherapeutic agents such as fludarabine injection and sodium fludarabine phosphate injection to kill leukemic cells, thereby inhibiting the growth and spread of leukemia cells.

In addition to the above, leukemic stem cells also release large numbers of leukemic cells, significantly increasing the proportion of leukemic cells in the patient's blood, further worsening the patient's condition.