How can cervical precancerous lesions occur without HPV?

Cervical precancerous lesions without HPV infection may be caused by unhealthy sexual practices, childbirth factors, genetic factors, and other reasons. A detailed analysis is as follows:

1. Unhealthy Sexual Practices

Engaging in sexual activity before the age of 16, having multiple sexual partners, or not using condoms during intercourse—these unhealthy sexual behaviors may lead to abnormal proliferation of squamous epithelium in the cervical mucosa.

2. Childbirth Factors

A history of multiple vaginal deliveries, early childbirth, or frequent induced abortions may cause damage to the genital organs, making them susceptible to repeated infections from pathogenic microorganisms, thereby leading to persistent abnormal proliferation of squamous epithelium in the cervical transformation zone.

3. Genetic Factors

If multiple family members have a history of cervical cancer, the patient may possess a genetic predisposition to tumors, resulting in inherited gene mutations associated with cervical cancer development.

In addition, long-term smoking, oral contraceptive use, and cervical inflammation may also contribute. Under medical guidance, chemotherapy drugs such as paclitaxel injection, cisplatin injection, and carboplatin injection can be used for treatment. For cases unresponsive to medication, surgical interventions such as cervical conization, loop electrosurgical excision procedure (LEEP), or hysterectomy may be considered.