Is physostigmine a cholinesterase inhibitor?

May 10, 2023 Source: Cainiu Health
Dr. Jiang Weimin
Introduction
Physostigmine is a cholinesterase inhibitor. Clinically, physostigmine has the effects of miosis and intraocular pressure reduction, and belongs to the class of anticholinesterase agents. This drug inhibits cholinesterase activity; in small doses, it can excite the nervous system, while in large doses, it may cause inhibition. It is particularly suitable for reversing central toxic effects caused by anticholinergic drugs.

Physostigmine is generally a cholinesterase inhibitor that helps reverse central toxic effects caused by anticholinergic drugs. The detailed analysis is as follows:

The main active ingredient of physostigmine is physostigmine sulfate. Clinically, it has effects of miosis and intraocular pressure reduction, and belongs to the class of anticholinesterase agents. This drug typically exhibits reversible inhibition of cholinesterase similar to neostigmine. When used in small doses on the nervous system, it may produce excitation; however, large doses may lead to inhibition. It is particularly suitable for reversing central toxic effects induced by anticholinergic agents, and can also be used in treating acute glaucoma and accommodative esotropia caused by hyperopia.

Physostigmine should generally be administered under the guidance of a physician to prevent blind or inappropriate use of the drug, which could lead to adverse reactions in the body.