What does atypical squamous cells (ASC-H) mean?

May 10, 2023 Source: Cainiu Health

Dr. Lv Aiming

Introduction

ASC-H (Atypical Squamous Cells, cannot exclude High-grade squamous intraepithelial lesion) means that abnormal squamous cells are found in the cervical cell sample, such as abnormalities in cell morphology and chromatin features, suggesting a possible precancerous condition, which requires heightened vigilance. It is recommended to follow medical advice for further testing, including HPV testing and cervical biopsy, to facilitate early detection of cervical precancerous lesions or cervical cancer.

ASC-H (Atypical Squamous Cells - cannot exclude HSIL) generally indicates a potential for malignant transformation of cervical cells. The specific analysis is as follows:

In clinical practice, ASC-H refers to results from a cervical exfoliative cytology report, indicating that abnormal squamous cells with atypical proliferation—such as abnormal cell morphology and chromatin characteristics—have been found in the cervical sample during a TCT test. This suggests a possible precancerous lesion, warranting close attention. It is recommended to undergo further examinations such as HPV testing and cervical biopsy under medical guidance, which helps detect early cervical lesions or cervical cancer at an early stage.

After an ASC-H diagnosis, patients are advised to actively follow medical advice and receive proper treatment to improve prognosis and prevent disease progression from affecting daily life and activities.

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What does atypical squamous cells mean, and is it serious?

Atypical squamous cells usually refer to cervical cellular changes, which may be caused by chronic inflammation leading to long-term irritation of cervical epithelial cells. Patients generally do not have obvious symptoms, although some may experience increased vaginal discharge, yellowish discharge, or itching of the external genitalia. If patients do not have significant discomfort, the condition is typically not serious and does not require specific treatment.

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What does a positive TCT (thin-layer liquid-based cytology test) result mean?

The purpose of liquid-based thin-layer cytology testing is to analyze the morphology of exfoliated cervical cells. If changes in cervical cells are detected, the result will be reported as positive. Positive findings may include low-grade precancerous lesions, high-grade precancerous lesions, cervical cancer, or atypical squamous cells. In such cases, it is recommended to further complete HPV testing of the cervix.

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Does ASC-US with a negative HPV result mean cancer?

ASC-US generally belongs to atypical squamous cells of undetermined significance. It may result from abnormal vaginal discharge infected by bacteria, although human papillomavirus (HPV) has not been detected, possibly due to testing errors. When ASC-US is present but HPV test is negative, it usually does not have significant clinical implications and is often considered a result of inflammatory reactions in the body, which typically can resolve spontaneously.

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How many years does it usually take for atypical squamous cells to become cancerous?

Atypical squamous refers to atypical squamous cells. The time it takes for atypical squamous cells to progress to cancer varies from several decades to a few months, depending on the risk level and pathological severity of the cancer. If atypical squamous cells are found, HPV testing can be used for confirmation. If only atypical squamous cells are present and all other tests are negative, further management may depend on clinical evaluation.

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What does "atypical squamous cells" mean? Is it serious? Does it mean cancer?

In general, atypical squamous cells refer to abnormal cellular changes observed in cytological examinations. They usually indicate morphological abnormalities in squamous epithelial cells and are typically not cancerous, but rather precancerous lesions. Further tests are necessary to determine the nature of these cells. Patients are advised to seek medical attention promptly and receive appropriate treatment accordingly.

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Is a positive result for atypical squamous cells serious?

Whether a positive result for atypical squamous cells is serious depends on the specific circumstances. If there is only mild morphological irregularity, it is usually not severe. However, if there is an HPV infection, the condition may be more serious. If test results indicate a high-risk HPV infection or precancerous cervical lesions, timely further evaluation and treatment are necessary to prevent disease progression.

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Is it serious if HPV31 is positive and TCT shows atypical squamous cells of undetermined significance?

HPV31 positive generally refers to human papillomavirus (HPV) type 31 infection. HPV type 31 infection with TCT showing atypical squamous cells of undetermined significance (ASC-US) is usually considered relatively serious. An HPV type 31 infection indicates the presence of a viral infection in the body and belongs to the high-risk category; when combined with TCT results showing atypical squamous cells of undetermined significance, the risk of malignant transformation is relatively high.

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Are atypical squamous cells cancer?

Atypical squamous cells are usually not cancerous, but they may indicate that cells are undergoing changes associated with precancerous conditions or early-stage cancer, thus requiring attention. It is recommended that after atypical squamous cells are detected, further examinations—such as a biopsy—be performed as directed by a physician to confirm the presence of malignancy. Prompt medical consultation and adherence to medical advice for treatment are advised.

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