What are the five manifestations after HBV small three positives turn negative?

After the "minor three positive" pattern of hepatitis B turns negative, there are usually no obvious symptoms, but certain changes may occur such as improved liver function, reduced viral replication, improved liver fibrosis, changes in serological markers, and prevention of hepatitis B virus transmission. The details are as follows:

1. Improved Liver Function

After turning negative, liver function indicators such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) gradually return to normal levels, indicating progressive improvement in liver function.

2. Reduced Viral Replication

Following immune system activation that eliminates or suppresses viral replication, the level of viral replication progressively declines and may eventually cease.

3. Improved Liver Fibrosis

A negative conversion indicates effective control or clearance of the hepatitis B virus in the body. Liver cells gradually regain normal function, helping to prevent or slow the progression of liver fibrosis.

4. Changes in Serological Markers

After the minor three positive pattern turns negative, changes in serological markers may occur—for example, hepatitis B surface antigen (HBsAg), hepatitis B core antibody (anti-HBc), and hepatitis B e antibody (anti-HBe) may convert from positive to negative.

5. Prevention of Hepatitis B Virus Transmission

After turning negative, patients are no longer infectious, effectively preventing the spread of the hepatitis B virus.

In addition, patients may experience increased body weight, improved appetite, reduced fatigue, and enhanced mood. It is recommended to maintain healthy lifestyle and dietary habits, engage in appropriate physical activity, and strengthen overall physical health.