What are the symptoms of high apolipoprotein A1 in women?

In women, elevated apolipoprotein A1 levels typically do not cause obvious symptoms if caused by physiological factors. However, if the elevation is due to underlying diseases such as hyperlipidemia or alcoholic hepatitis, symptoms related to those conditions may appear. The details are as follows:

I. Physiological Factors

During pregnancy, women may consume excessive high-fat foods to support fetal development. These high-fat foods can lead to increased lipid accumulation in the body, resulting in elevated apolipoprotein A1 and total cholesterol levels. This is considered a physiological change and generally does not produce noticeable symptoms. However, pregnant women should pay attention to their diet and limit intake of fatty foods.

II. Pathological Factors

1. Hyperlipidemia

This condition refers to elevated levels of cholesterol and triglycerides in the plasma. It commonly affects individuals who are overweight or obese. Patients often have high body fat levels, and when excess fat accumulates in the liver, apolipoprotein A1 levels may rise above the normal range. If lipids deposit around the eyelids, they can cause xanthelasma. Additionally, large triglyceride-rich lipoproteins depositing in the small arteries of the retina may lead to changes in the fundus. Treatment may include medications such as simvastatin tablets or rosuvastatin calcium tablets, as directed by a physician.

2. Alcoholic Hepatitis

Long-term excessive alcohol consumption increases the burden on the liver and causes liver damage, which can alter apolipoprotein A1 levels since this protein is primarily synthesized in the liver. In early stages, there may be no obvious symptoms. As liver function deteriorates, liver fibrosis may develop, leading to symptoms such as fatigue, decreased appetite, and pain in the liver area. Medications such as prednisone acetate tablets or silymarin capsules may be prescribed under medical supervision.

In addition to the above causes, elevated apolipoprotein A1 may also be associated with coronary atherosclerotic heart disease. Individuals experiencing the aforementioned symptoms should seek prompt medical evaluation at a hospital.