Is elevated alpha-hydroxybutyrate dehydrogenase severe?

Alpha-hydroxybutyrate dehydrogenase (α-HBDH) is an enzyme involved in the metabolic pathway of lactate. Elevated levels of α-HBDH often indicate changes associated with certain diseases or physiological conditions, such as myocardial injury, liver disease, and muscular disorders. However, this does not necessarily mean the condition is severe. The specific analysis is as follows:

I. Not Severe

In conditions of hypoxia at high altitudes, α-HBDH levels may also rise. In such cases, simply administering oxygen promptly and removing the individual from the low-oxygen environment can restore α-HBDH levels to normal.

II. Severe

1. Myocardial Injury
When myocardial damage occurs, α-HBDH is released into the bloodstream, leading to elevated blood levels of α-HBDH.

2. Liver Disease
Liver diseases such as hepatitis and cirrhosis can also cause increased levels of α-HBDH in the blood.

3. Muscular Disorders
Certain muscle diseases, such as amyotrophic lateral sclerosis (ALS), may also lead to elevated α-HBDH levels.

It is important to note that elevated α-HBDH levels alone cannot be used as a definitive basis for diagnosing diseases or assessing the severity of illness. Comprehensive evaluation must include other clinical indicators and diagnostic test results. If abnormal α-HBDH levels are detected, it is recommended to seek medical attention promptly for further examinations and appropriate treatment to identify the underlying cause and develop a suitable treatment plan.