What is ctDNA testing used for?

Generally, ctDNA, or circulating tumor DNA, refers to DNA fragments released into the bloodstream when tumor cells die or undergo apoptosis. ctDNA is used for tumor detection. The specific details are as follows:

ctDNA is a testing method that diagnoses and monitors tumors by detecting tumor-derived DNA in the blood. As it consists of DNA fragments shed by tumor cells into the bloodstream, this approach is also known as liquid biopsy. Carrying genetic information from the tumor, ctDNA can reflect the presence, quantity, and genetic mutations of the tumor. During testing, doctors collect a blood sample from the patient and use various laboratory techniques and analytical methods to isolate and identify ctDNA. These techniques include PCR amplification and next-generation sequencing (NGS). Based on the test results, physicians can determine whether a tumor is present, identify its type, size, differentiation level, and detect any genetic mutations. In clinical practice, this test can be applied in early screening, risk assessment, disease diagnosis, and treatment response evaluation.

Therefore, ctDNA testing is a novel, non-invasive method that provides reliable support for the diagnosis, treatment, and monitoring of cancer patients.