What are the risks of low 25-hydroxy vitamin D2?

Generally, low levels of 25-hydroxyvitamin D2 may lead to adverse effects such as impaired calcium absorption, osteoporosis, and osteomalacia. A detailed analysis is as follows:

1. Impaired Calcium Absorption

25-Hydroxyvitamin D2 is typically synthesized in the body through ultraviolet light exposure and obtained from dietary sources. When levels of 25-hydroxyvitamin D2 are deficient, blood calcium levels may drop, impairing the body's ability to absorb calcium. This can result in symptoms such as pain and seizures. Patients can enhance calcium absorption by increasing sun exposure.

2. Osteoporosis

In clinical practice, 25-hydroxyvitamin D2 is also known as active vitamin D and is considered a hormone. When this hormone is deficient, it impairs intestinal calcium absorption, reduces calcium salt deposition in bones, and decreases bone mass, leading to osteoporosis. Patients may require treatment with parathyroid hormone injections and oral vitamin D supplements under medical supervision.

3. Osteomalacia

Long-term deficiency of this substance disrupts calcium and phosphorus metabolism, causing bone softening and deformities. Patients can take vitamin D2 and calcium carbonate tablets, among other medications, under a doctor's guidance to alleviate symptoms.

Besides the above conditions, vitamin D2 deficiency may also be associated with depression, rickets, and diabetes. Patients should seek timely medical evaluation and treatment when experiencing any health issues.