Hands are prone to cracking, followed by blistering without itching.

Hand peeling and blistering without itching may be related to factors such as hyperhidrosis, dyshidrotic eczema, or tinea manuum, and appropriate medication should be used for treatment. Specific analyses are as follows:

1. Hyperhidrosis

This condition involves abnormal excessive sweating of the localized or entire skin surface. Excessive hand sweating over a prolonged period leads to skin maceration from sweat, damaging the skin barrier and resulting in peeling and blistering without itching. Treatment should follow medical advice using medications such as Acanthopanax senticosus tablets, vitamin B1 tablets, and oryzanol tablets.

2. Dyshidrotic Eczema

A vesicular skin disorder caused by contact allergens, skin infections, or other factors, leading to dysfunction of the nervous system in the hands. This results in easy skin breakdown and blister formation. Medical treatment with oral antihistamines such as chlorpheniramine maleate, loratadine, or desloratadine tablets should be followed as prescribed.

3. Tinea Manuum

A fungal infection causing skin disease, which leads to keratin layer disintegration and abnormal keratinocyte proliferation, resulting in skin peeling and localized blisters without significant itching. Treatment under medical guidance includes antifungal agents such as terbinafine hydrochloride tablets, itraconazole capsules, and bifonazole cream.

Besides the above causes, similar symptoms may also result from hand-foot eczema, palmoplantar pustulosis, or herpes zoster. When discomfort occurs on the hands, prompt medical evaluation is necessary to determine the exact cause and initiate appropriate treatment to promote recovery.