A small fluid-filled blister has developed in the center of the palm.

Small blisters usually refer to tiny vesicles. The appearance of small blisters in the center of the palm may be caused by conditions such as dyshidrotic eczema, general eczema, or tinea manuum (fungal infection of the hands), and can be improved with medication. Specific analyses are as follows:

1. Dyshidrotic Eczema

Dyshidrotic eczema is typically a vesicular skin disorder affecting the palms of the hands or soles of the feet. It mainly presents as small, deep-seated blisters that are densely distributed, accompanied by itching and a burning sensation. Under medical guidance, patients may use medications such as miconazole nitrate cream, compound povidone-iodine lotion, or urea ointment.

2. Eczema

If a patient does not maintain proper hygiene of the palms, eczema can easily develop. Local symptoms include small blisters and itching, which may lead to secondary infection and recurrent episodes if scratched. Patients may follow medical advice to use medications such as boric acid and zinc oxide ointment, calamine lotion, or desonide cream.

3. Tinea Manuum (Hand Fungus)

Tinea manuum is generally caused by dermatophyte infection of the skin on the hands, possibly leading to significant skin damage along with symptoms such as peeling, blisters, and dryness. With professional medical assistance, medications such as naftifine-ketoconazole cream, compound ketoconazole ointment, or salicylic acid ointment can be used to relieve symptoms.

Besides the above causes, similar symptoms could also result from palmoplantar pustulosis, contact dermatitis, hand-foot-and-mouth disease, or other conditions. It is recommended to seek timely medical evaluation at a hospital; self-medication should be avoided. In daily life, maintain good personal hygiene and avoid scratching other parts of the body with affected hands.