What does elevated lactate dehydrogenase and elevated hydroxybutyrate dehydrogenase indicate?

Elevated lactate dehydrogenase (LDH) and hydroxybutyrate dehydrogenase (HBDH) levels indicate cellular or tissue damage, which is commonly associated with conditions such as pneumonia, viral hepatitis, and pancreatitis. Patients may be treated with medications or surgical interventions depending on the cause. Specific analyses are as follows:

1. Pneumonia

Pneumonia refers to inflammatory changes in lung tissue. When lung cells are damaged or necrotic due to inflammation, the concentrations of lactate dehydrogenase and hydroxybutyrate dehydrogenase in the blood may increase, accompanied by symptoms such as cough and sputum production. Patients can take medications such as levofloxacin hydrochloride capsules or cefixime capsules under medical guidance to improve their condition.

2. Viral Hepatitis

After viral infection, liver cells may be damaged, leading to inflammatory changes in the liver and the release of large amounts of lactate dehydrogenase and hydroxybutyrate dehydrogenase into the bloodstream. This is often accompanied by symptoms such as liver area pain, aversion to oily foods, and nausea. Patients can be treated with antiviral medications such as ribavirin dispersible tablets or entecavir maleate tablets under medical supervision.

3. Pancreatitis

Pancreatitis refers to non-infectious inflammatory changes in the pancreas. Inflammation can cause symptoms such as abdominal pain, nausea, vomiting, and fever, along with elevated levels of lactate dehydrogenase and hydroxybutyrate dehydrogenase. In some cases, surgical treatment may be necessary, such as percutaneous drainage or laparoscopic resection, performed under medical guidance.

In addition to the common causes mentioned above, elevated LDH and HBDH levels may also be related to fatty liver, nephritis, myocardial infarction, or liver cirrhosis. If patients experience other discomforts, they should seek timely medical evaluation at a hospital.