Which diseases can cause elevated levels of lambda light chains?

Skin amyloidosis, diabetes, nephrotic syndrome, and other conditions can cause elevated levels of LAM light chains, which may be alleviated through physical or pharmacological treatments. Specific analyses are as follows:

1. Skin Amyloidosis

Skin amyloidosis is a dermatological condition caused by the deposition of amyloid substances in tissues, which may lead to papules, hypopigmentation, and elevated LAM light chain levels. Treatments such as laser therapy and liquid nitrogen cryotherapy can inhibit cell proliferation.

2. Diabetes

Diabetes is often triggered by elevated blood glucose and blood pressure levels, potentially causing kidney damage and resulting in increased immunoglobulin LAM light chains. Medications such as dorogliatin tablets or dapagliflozin tablets may be used under medical supervision.

3. Nephrotic Syndrome

In patients with nephrotic syndrome, excessive proteinuria following disease onset may lead to the aforementioned condition. Treatment may include medications such as prednisone acetate tablets or cyclophosphamide tablets, taken as directed by a physician.

Besides the above-mentioned diseases, acute and chronic hepatitis, liver cirrhosis, and multiple myeloma may also contribute. Patients are advised to promptly seek hospital evaluation for further testing to rule out malignant conditions and actively intervene once the underlying cause is identified.