Why should isosorbide mononitrate be taken on an empty stomach in the morning?
Jun 10, 2023
Source: Cainiu Health
Dr. Yang Shuwen
Introduction
"Mononitrate" usually refers to isosorbide mononitrate, which is commonly available in tablet, capsule, and sustained-release formulations. Isosorbide mononitrate is generally recommended to be taken on an empty stomach in the morning. This practice is typically associated with improved drug absorption, reduced adverse reactions, and stabilized drug concentration. Additionally, taking it in the morning may help minimize gastrointestinal discomfort, promote rapid absorption, and prolong the drug's effectiveness.
Mononitrate usually refers to isosorbide mononitrate, which is commonly available in tablets, capsules, and sustained-release formulations. It is generally recommended to take isosorbide mononitrate on an empty stomach in the morning, a practice associated with improved drug absorption, reduced adverse reactions, and stabilized drug concentration. Specific details are as follows:
1. Improved drug absorption: Isosorbide mononitrate must be absorbed through the gastrointestinal tract. When taken on an empty stomach in the morning, the absence of food and other medications allows for faster absorption, thereby enhancing therapeutic effectiveness.
2. Reduced adverse reactions: Isosorbide mononitrate is a vasodilator that may cause adverse effects such as hypotension. Taking it on an empty stomach minimizes potential interactions with food or other drugs, thus lowering the risk of adverse reactions.
3. Stabilized drug concentration: The duration of action of isosorbide mononitrate is relatively short, necessitating multiple daily doses. Taking the first dose on an empty stomach in the morning helps maintain more stable blood drug levels, reducing fluctuations in efficacy and dosage errors.
In addition, taking the medication on an empty stomach may also help reduce gastrointestinal discomfort, enable quicker absorption, and prolong therapeutic effects. It is important to note that isosorbide mononitrate should be taken exactly as directed by a physician to avoid unnecessary risks.
