Why does taking PEP medication cause low-grade fever?

HIV prophylaxis usually refers to post-exposure prophylaxis (PEP) for HIV, and low-grade fever generally means mild fever. In general, experiencing a low-grade fever while taking HIV prophylactic medication may be related to drug side effects, common cold, HIV infection, or other causes. The specific details are as follows:

1. Drug Side Effects

Taking HIV prophylactic medication may lead to side effects such as nausea, vomiting, diarrhea, headache, dizziness, rash, fatigue, and fever, with the fever often presenting as low-grade. This condition is usually not severe. It is recommended that patients get adequate rest and maintain a light diet; symptoms typically resolve on their own after some time.

2. Common Cold

If patients become overly anxious after taking HIV prophylactic medication and fail to keep warm, they may catch a cold, leading to symptoms such as runny nose, fever, and sneezing, which could result in the aforementioned condition. It is recommended that patients follow medical advice and take medications such as Lingyang Cold Capsules or Cold Cough Tablets for treatment.

3. HIV Infection

If high-risk sexual behavior occurred more than 72 hours before starting HIV prophylactic medication, the effectiveness of the prophylaxis may be compromised, potentially resulting in prevention failure and subsequent HIV infection. Symptoms may include fever (typically low-grade), night sweats, and diarrhea. It is recommended that patients follow medical guidance and use antiretroviral drugs such as Nevirapine Tablets or Lamivudine Capsules to prolong survival and improve quality of life.

Besides the above, other possible causes include hyperthyroidism, tuberculosis, leukemia, lung cancer, etc. It is advised that individuals seek prompt medical attention after any high-risk behavior and strictly adhere to medical instructions when taking HIV prophylactic medication, avoiding complacency to prevent adverse outcomes.