What are the contraindications and side effects of enteric-coated erythromycin tablets?
Aug 24, 2023
Source: Cainiu Health
Dr. Yang Shuwen
Introduction
In general, contraindications for erythromycin enteric-coated tablets include hypersensitivity to macrolide antibiotics, and caution should be exercised in pregnant women, nursing mothers, and patients with hepatic or renal insufficiency. Side effects may include diarrhea, fatigue, abdominal pain, oral and tongue pain, and arrhythmias. Patients are advised to use the medication as directed by their physician and to seek medical attention promptly if any adverse reactions occur.
Under normal circumstances, contraindications for erythromycin enteric-coated tablets include: individuals allergic to macrolide antibiotics should not use it; pregnant women, nursing mothers, patients with hepatic insufficiency, and patients with renal insufficiency should use it cautiously. Side effects may include diarrhea, fatigue, abdominal pain, oral or tongue pain, and arrhythmia. Specific details are as follows:
I. Contraindications
1. Allergy to macrolide antibiotics (contraindicated): Erythromycin enteric-coated tablets are contraindicated in patients who have an allergic reaction or a history of severe allergy to macrolide antibiotics such as erythromycin. Allergic reactions may include rash, urticaria, difficulty breathing, and edema.
2. Use with caution during pregnancy: The use of erythromycin enteric-coated tablets in pregnant women should be cautious. Although erythromycin is considered a low-toxicity drug, potential effects on the fetus must still be considered when used during pregnancy.
3. Use with caution during breastfeeding: The active ingredient in erythromycin enteric-coated tablets—erythromycin—can be excreted into breast milk and transferred to the infant. Therefore, its use in nursing mothers should be approached with caution.
4. Use with caution in patients with hepatic insufficiency: After absorption, erythromycin enteric-coated tablets are primarily metabolized by the liver. Therefore, their use in patients with impaired liver function requires caution, as hepatic insufficiency may affect drug metabolism and elimination, leading to increased drug accumulation and risk of adverse effects.
5. Use with caution in patients with renal insufficiency: Following absorption, erythromycin enteric-coated tablets are mainly excreted through the kidneys. In patients with impaired kidney function, drug clearance may be reduced, increasing the risk of drug toxicity and side effects. Hence, caution is required in such patients.
II. Side Effects
1. Diarrhea: Erythromycin enteric-coated tablets may disrupt the normal balance of intestinal flora, leading to diarrhea. This diarrhea is usually mild to moderate and typically resolves spontaneously after discontinuation of the drug.
2. Fatigue: Fatigue is a common side effect of erythromycin enteric-coated tablets. It may result from the drug's impact on the body, causing feelings of tiredness and weakness.
3. Abdominal pain: Some patients may experience abdominal pain or discomfort after taking erythromycin enteric-coated tablets. This is generally due to irritation of the gastrointestinal tract or intestinal spasms caused by the medication.
4. Oral or tongue pain: Pain in the mouth or tongue is a relatively uncommon side effect of erythromycin enteric-coated tablets. Patients may experience a burning or tingling sensation in the oral cavity or tongue, which could affect eating and oral hygiene.
5. Arrhythmia: Erythromycin enteric-coated tablets may induce arrhythmias, particularly when used at high doses or in patients with pre-existing heart conditions. Arrhythmia refers to abnormal heart rhythms and may manifest as palpitations, tachycardia, or bradycardia. If symptoms of arrhythmia occur, immediate medical attention is required.
Patients are advised to take the medication strictly as prescribed. If any adverse reactions occur, prompt medical consultation is recommended. Proper treatment under medical supervision can facilitate recovery.
