Is an indirect bilirubin level of 15.8 μmol/L considered high?

Elevated indirect bilirubin is primarily associated with various hemolytic diseases. A level of 15.8 μmol/L for indirect bilirubin is generally considered high.

The increase in indirect bilirubin mainly results from the destruction of large numbers of red blood cells, leading to the conversion of substantial amounts of hemoglobin into indirect bilirubin. Under normal circumstances, indirect bilirubin remains stable, typically ranging between 1.7 and 10.2 μmol/L. Therefore, a measured level of 15.8 μmol/L indicates an elevated value. Conditions such as acute liver necrosis, acute jaundice-causing hepatitis, and chronic active hepatitis may lead to increased levels of indirect bilirubin in the blood. For example, in acute liver necrosis, impaired liver function may prevent bile from being excreted normally, causing bilirubin to accumulate in the bloodstream and increasing indirect bilirubin levels. Similarly, in acute jaundice-causing hepatitis, damaged liver cells may fail to process bilirubin properly, resulting in its accumulation in the blood and consequently elevated indirect bilirubin.

If the elevation in indirect bilirubin is significant, it is advisable to seek medical attention at a hospital as early as possible. Comprehensive evaluation through tests such as complete blood count, liver ultrasound, CT scan, or MRI should be performed, and appropriate treatment should be initiated based on the findings.