What is dysgenesis of the cavity of the septum pellucidum?

The cavum septum pellucidum is generally a brain structure composed of two triangular thin glial membranes. Its underdevelopment may be caused by genetic factors, environmental factors, chromosomal abnormalities, cardiac defects, or brain malformations. The specific analysis is as follows:

1. Genetic Factors

If parents are closely related by blood, recessive disease-causing genes may become expressed. Gene mutations in one or both parents, or inherited congenital brain disorders, can all affect the development of the cavum septum pellucidum, leading to its underdevelopment.

2. Environmental Factors

Environmental factors encountered during embryonic development may impact heart development. For example, maternal infections, exposure to harmful substances or medications, or poor nutritional status during pregnancy may negatively affect the normal development of the cavum septum pellucidum.

3. Chromosomal Abnormalities

Chromosomal abnormalities, such as abnormal chromosome number or structural defects, may interfere with the normal formation of the cavum septum pellucidum during embryonic development. Common chromosomal disorders like Down syndrome and Edwards syndrome may be associated with underdevelopment of the cavum septum pellucidum.

4. Cardiac Defects

Certain heart defects, such as ventricular septal defect or bicuspid aortic valve, may be associated with underdevelopment of the cavum septum pellucidum, as the development of different parts of the embryonic heart is interrelated and mutually influential.

5. Brain Malformations

The presence of brain malformations such as corpus callosum abnormalities, porencephaly, severe hydrocephalus, or brain tumors may all lead to developmental abnormalities of the cavum septum pellucidum, including malformation or absence.

For patients with mild conditions, treatment may involve taking neuro-nutritional medications orally as directed by a physician, such as mecobalamin tablets or vitamin B supplements. If drug therapy proves ineffective or the condition is severe, surgical interventions such as corrective surgery or cerebrospinal fluid drainage may be required under medical guidance based on individual circumstances. In daily life, it is important to maintain healthy habits and follow a light, nutritious diet. Once underdevelopment of the cavum septum pellucidum is detected, prompt medical evaluation and treatment are essential.