Does B2704 subtype positivity require treatment?

In general, a positive B*2704 subtype requires treatment. The specific analysis is as follows:

A positive B*2704 subtype refers to the presence of human leukocyte antigen (HLA)-B27 subtype 04, meaning HLA-B27 positivity. Under normal circumstances, this may indicate conditions such as ankylosing spondylitis, reactive arthritis, or psoriatic arthritis. Patients with ankylosing spondylitis are advised to follow medical guidance for treatment with medications such as adalimumab injection or hydroxychloroquine sulfate tablets; those with reactive arthritis should follow medical advice using celecoxib capsules or methylprednisolone tablets; patients with psoriatic arthritis are recommended to take sulfasalazine enteric-coated tablets or celecoxib capsules as directed by their physician.

If patients experience any discomfort symptoms, they should promptly seek medical attention at a hospital to avoid delaying diagnosis and treatment.