Does a positive HLA-B27 test definitely mean ankylosing spondylitis?
Oct 17, 2023
Source: Cainiu Health
Dr. Zhang Xuewu
Introduction
Ankylosing spondylitis is an inflammatory disease characterized primarily by symptoms such as low back pain, pain in the buttocks and heels, morning stiffness, and spinal deformity. It typically develops between the ages of 16 and 40 and is associated with the HLA-B27 gene. A positive HLA-B27 test result is determined through a blood test and serves as one of the diagnostic indicators; clinically, patients with this condition often show a positive HLA-B27 result.
In general, a positive HLA-B27 test does not necessarily mean ankylosing spondylitis. The specific analysis is as follows:
Ankylosing spondylitis is an inflammatory disease characterized by symptoms such as back and buttock pain, heel pain, morning stiffness, and spinal deformity. It typically develops between the ages of 16 and 40 and is associated with the HLA-B27 gene. A positive HLA-B27 result from a blood test indicates a higher risk of developing ankylosing spondylitis compared to the general population. However, this single test alone is insufficient to confirm the diagnosis. Further evaluation through physical examination, imaging studies, and laboratory tests is required. Only when all these findings meet established diagnostic criteria can a definitive diagnosis of ankylosing spondylitis be made. Once diagnosed, treatment may include medications such as ibuprofen tablets, sulfasalazine enteric-coated tablets, and methotrexate tablets, as prescribed by a physician. Additionally, physical therapies like warm baths or showers may help accelerate recovery. Patients should avoid excessive fatigue during illness to prevent worsening symptoms.
Patients are advised to seek timely medical attention when experiencing symptoms and to undergo standardized treatment under a doctor's guidance, which helps promote recovery.
