Elevated gamma globulin in protein electrophoresis

Under normal circumstances, protein electrophoresis γ usually refers to γ-globulin. γ-Globulin is a type of protein electrophoresis with a reference range of 4%–13%. Therefore, a γ-globulin level exceeding 13% indicates an elevated value. Elevated γ-globulin levels may be caused by factors such as poor lifestyle habits, alcoholic hepatitis, acute nephritis, systemic lupus erythematosus, or cirrhosis. Patients are advised to seek timely medical evaluation and follow medical guidance for treatment. Specific analyses are as follows:

1. Poor Lifestyle Habits

If an individual drinks insufficient water in daily life, leading to blood concentration, or engages in behaviors such as staying up late or excessive alcohol consumption, the body's immune function may become compromised, potentially causing a transient increase in γ-globulin. This is considered a normal physiological phenomenon and typically resolves on its own.

2. Alcoholic Hepatitis

Prolonged alcohol consumption may overload the liver, impairing liver function and potentially increasing γ-globulin levels. Treatment under medical supervision may include medications such as polyene phosphatidylcholine capsules, metadoxine tablets, or reduced glutathione for injection.

3. Acute Nephritis

This condition is typically caused by acute inflammatory changes in the kidneys, which may lead to increased γ-globulin levels. Treatment usually involves taking medications as prescribed by a physician, such as nifedipine sustained-release tablets, amoxicillin capsules, or hydrochlorothiazide tablets.

4. Systemic Lupus Erythematosus (SLE)

SLE is triggered by factors such as genetic predisposition and elevated estrogen levels, which disrupt the body's immune system. Laboratory tests often show elevated γ-globulin levels. Common symptoms include fever, butterfly-shaped rashes, muscle pain, and other discomforts. Under medical guidance, treatments may include ibuprofen sustained-release capsules, cyclophosphamide tablets, or methylprednisolone tablets.

5. Cirrhosis

Cirrhosis is typically caused by chronic liver damage, resulting in increased antibody production, which easily leads to elevated γ-globulin levels. Treatment requires adherence to medical advice and may involve medications such as lamivudine tablets, prednisone acetate tablets, or bumetanide tablets.

In addition, elevated γ-globulin levels could also be caused by pancreatic cancer. It is essential to seek medical attention for targeted diagnosis and treatment to avoid delays in managing the underlying condition.