HPV16/18 TCT low-grade biopsy usually shows what results

HPV16/18 TCT refers to HPV16 TCT and HPV18 TCT, respectively. Under normal circumstances, low-grade biopsy results for HPV16 TCT may include normal findings, inflammatory response, cervical intraepithelial neoplasia (CIN), squamous intraepithelial lesion (SIL) of the cervix, or cervical cancer; low-grade biopsy results for HPV18 TCT generally include normal findings, cervical intraepithelial neoplasia grade 1 (CIN1), CIN2, CIN3, or cervical cancer. The detailed analysis is as follows:

I. HPV16 TCT

1. Normal Results

Although HPV16 is classified as a high-risk HPV type, it does not necessarily indicate the presence of cervical lesions. A low-grade TCT result indicates that the cervical liquid-based cytology test is normal. In some cases, the body's immune system can clear the virus, and the biopsy result may be completely normal. Patients in this situation do not need to be overly concerned.

2. Inflammatory Response

Cervical inflammation is a common gynecological condition. Among patients who are HPV16-positive with a low-grade TCT result, some may have only an inflammatory reaction. In such cases, biopsy results may show infiltration of inflammatory cells. These patients should receive anti-inflammatory treatment under medical guidance.

3. Cervical Intraepithelial Neoplasia (CIN)

Cervical intraepithelial neoplasia refers to abnormal proliferation of cervical epithelium and is classified into three grades. If the biopsy shows CIN1, it indicates mild dysplasia and a relatively mild condition. If the result shows CIN2 or CIN3, the condition is more severe, and patients require surgical intervention under medical supervision.

4. Squamous Intraepithelial Lesion (SIL) of the Cervix

This is a specific type of cervical intraepithelial neoplasia, also divided into three grades based on severity. If the biopsy reveals SIL grade 1 or 2, patients should closely monitor changes in their condition. If the result is SIL grade 3, the condition is serious and requires surgical treatment under medical guidance.

5. Cervical Cancer

If biopsy results reveal the presence of cancer cells, a diagnosis of cervical cancer may be made. In such cases, prompt surgical treatment is required, and further treatment plans should be determined based on postoperative pathological findings.

II. HPV18 TCT

1. Normal Results

HPV18 is also a high-risk human papillomavirus type, but its presence does not automatically imply cervical lesions. A low-grade TCT result indicates normal cervical liquid-based cytology. The body's immune system often clears the virus naturally, and biopsy results may appear normal.

2. Cervical Intraepithelial Neoplasia Grade 1 (CIN1)

A low-grade biopsy result for HPV18 TCT may show CIN1. CIN1 represents mild abnormal proliferation of cervical epithelium and typically does not require specific treatment. In such cases, patients are advised to undergo regular cervical cytology tests and HPV testing to monitor disease progression.

3. Cervical Intraepithelial Neoplasia Grade 2 (CIN2)

A low-grade biopsy result for HPV18 TCT may indicate CIN2. CIN2 represents moderate abnormal proliferation of cervical epithelium, and patients at this stage require surgical treatment under medical supervision.

4. Cervical Intraepithelial Neoplasia Grade 3 (CIN3)

CIN3 represents severe abnormal proliferation of cervical epithelium. A low-grade biopsy result for HPV18 TCT may also show CIN3, in which case patients should promptly receive treatment—such as radiation therapy—as recommended by their physician.

5. Cervical Cancer

Although the probability is relatively low, there remains a possibility that a low-grade biopsy result for HPV18 TCT could indicate cervical cancer. In such cases, it is recommended that patients undergo surgical treatments such as cervical conization or total hysterectomy, based on tumor staging, overall health status, and other factors, under the guidance of a physician.

Patients are advised to seek timely medical attention if they experience any discomfort and to follow standardized treatment protocols under medical supervision, which helps promote recovery.