Can human brucellosis resolve spontaneously?

Brucellosis—commonly referred to as “brucellosis”—is a zoonotic infectious disease caused by bacteria of the genus *Brucella*. In most cases, human brucellosis does not resolve spontaneously; prompt medical consultation and treatment under a physician’s guidance are strongly recommended. A detailed analysis follows:

Brucellosis is caused by infection with *Brucella* bacteria and is primarily transmitted via the gastrointestinal tract, respiratory tract, or direct contact with skin or mucous membranes. Common symptoms include fever, profuse sweating, fatigue, myalgia, and arthralgia. Severe cases may involve lymphadenopathy, osteoarticular pain, and hepatic or renal dysfunction. Brucellosis typically does not resolve without treatment; untreated infection may progress chronically and, in severe instances, threaten life. Under medical supervision, patients may receive antibiotic therapy—for example, doxycycline hydrochloride capsules, rifampicin capsules, or amoxicillin capsules—which inhibits bacterial growth or eradicates the pathogen to control infection.

During treatment, patients should follow a light, bland diet and avoid spicy or irritating foods. Additionally, appropriate physical activity tailored to individual health status can help strengthen immune function. In daily life, close contact with animals infected with *Brucella*—particularly livestock such as cattle and sheep—should be avoided.