On the fourth day, the cold sore on the lip has ulcerated and is bleeding.

Jan 31, 2024 Source: Cainiu Health
Dr. Wang Xiaoyan
Introduction
On the fourth day, ulceration and bleeding of cold sores on the lips may typically result from improper diet, viral replication and disease progression, accumulation of herpes blister fluid, cellular inflammation and immune response, or secondary infection, requiring targeted management. It is recommended to seek medical attention promptly for diagnosis and treatment. Maintaining a light diet, drinking plenty of water, and engaging in moderate exercise in daily life may help promote recovery.

On the fourth day, bleeding and ulceration of lip herpes may typically result from improper diet, viral replication and disease progression, accumulation of herpes blister fluid, cellular inflammation and immune response, or secondary infection. Targeted management is required, and medical consultation is recommended as soon as possible. Detailed analysis is as follows:

1. Improper Diet

Diet can influence immune system function. Deficiencies in key nutrients such as vitamin C, vitamin E, and zinc may reduce the immune system's antiviral capacity, potentially worsening viral infection. Patients should maintain a balanced diet and increase intake of foods rich in these nutrients.

2. Viral Replication and Disease Progression

Lip herpes is caused by the herpes simplex virus, and viral replication is a key factor in disease development. After infection, the virus replicates within cells, leading to cell rupture and resulting in symptoms such as blister rupture and bleeding. Treatment under medical guidance may include medications such as acyclovir glucose injection, calamine lotion, and acyclovir cream.

3. Accumulation of Herpes Blister Fluid

Herpes blister fluid contains large numbers of viral particles, cellular debris, and inflammatory substances. When the blister ruptures, these contents may leak out, creating an eroded surface accompanied by bleeding. Treatment options based on physician recommendations may include recombinant human interferon α2b injection, valacyclovir hydrochloride granules, and ribavirin granules.

4. Cellular Inflammation and Immune Response

The immune system responds to viral infection by triggering inflammation, which may worsen herpes symptoms and make lesions more fragile and prone to rupture. Immune cell activity can also cause local blood vessel dilation and leakage, leading to bleeding. As directed by a physician, drugs such as sodium laoxacillin for injection, aztreonam for injection, and cefotaxime sodium and sulbactam sodium for injection may be used to alleviate symptoms.

5. Secondary Infection

Ruptured herpes lesions are susceptible to bacterial infection, which can exacerbate inflammation at the site and increase the risk of bleeding. Secondary infection may intensify pathological changes in the affected tissue. Patients must continue medication as prescribed by their doctor, taking the correct dosage at regular intervals, and avoid stopping treatment prematurely on their own.

It is recommended to maintain a light diet, drink plenty of water, and engage in moderate exercise in daily life to support recovery.