Is P16, KI67- caused by inflammation?

P16 and Ki-67 are indicators commonly referred to in cervical immunohistochemical examinations. These results may be caused by inflammation or other factors. Patients are advised to cooperate with their doctors for further evaluation and receive appropriate treatment based on the specific situation. The detailed analysis is as follows:

1. Yes

P16 is a type of immunohistochemical marker that helps determine whether precancerous lesions are present in cervical biopsy pathology. A negative P16 result indicates no precancerous changes. Ki-67 reflects the level of cellular proliferation activity; in the presence of a tumor, Ki-67 can help assess the tumor's malignancy and provide some insight into patient prognosis. If both P16 and Ki-67 are negative, it suggests that cervical changes have not reached the stage of precancerous lesions and may instead indicate an inflammatory response.

2. No

If cervical immunohistochemical testing shows both P16 and Ki-67 to be negative, the findings could still be associated with conditions such as cervical intraepithelial neoplasia, genital warts of the cervix, cervical ectropion, or cervical polyps. Patients may experience symptoms including abnormal vaginal bleeding, increased vaginal discharge, and vulvar itching. In such cases, the cause may not be primarily inflammatory, and patients should consult their doctors for additional diagnostic tests.

Under normal circumstances, maintain a light diet and avoid spicy, greasy, or irritating foods. If any abnormalities occur, seek medical attention promptly.