Does dacarbazine require light-protected infusion?

Dacarbazine generally needs to be administered with protection from light. Dacarbazine is commonly used in the treatment of malignant melanoma, soft tissue sarcomas, and malignant lymphomas. It usually requires light-protected infusion to prevent drug degradation.

Dacarbazine is highly photosensitive and prone to oxidation, which may reduce its efficacy and potentially generate harmful substances. Therefore, dacarbazine should be prepared immediately before use and administered promptly with protection from light after being dissolved with other medications. Light-protected infusion helps minimize drug oxidation and ensures therapeutic effectiveness. During infusion, light-protective measures such as using light-protected intravenous sets and light-shielded infusion bags should be employed to avoid direct exposure of the drug to light, thereby maintaining its stability. If complete light protection cannot be achieved, the infusion duration should be minimized as much as possible to reduce the impact of light exposure and allow dacarbazine to enter the patient's body quickly for effective treatment.

Since dacarbazine may increase skin sensitivity to light, patients should avoid direct sunlight after infusion. When going outdoors, it is recommended to wear long-sleeved clothing, a sun-protective hat, and apply sunscreen. If adverse reactions occur after infusion, medical attention should be sought promptly for timely management and symptom relief.