What is Compound Paracetamol and Amantadine Hydrochloride Tablets?

Compound Paracetamol and Amantadine Tablets are a medication with antipyretic (fever-reducing) and analgesic (pain-relieving) properties. They are indicated for the treatment of common cold symptoms such as nasal congestion, sore throat, headache, and fever, and also possess both prophylactic and therapeutic effects against influenza. The active ingredients include paracetamol (acetaminophen), amantadine hydrochloride, chlorpheniramine maleate, artificial bezoar, and caffeine; excipients include starch, sugar powder, and magnesium stearate. So, what exactly is Compound Paracetamol and Amantadine Tablets? The following section provides a detailed explanation.

Compound Paracetamol and Amantadine Tablets are antipyretic-analgesic agents. Their mechanism of action involves inhibiting the synthesis and release of prostaglandins in the hypothalamic thermoregulatory center, thereby inducing peripheral vasodilation. Key active ingredients include paracetamol, amantadine hydrochloride, caffeine, and chlorpheniramine maleate. Specifically, paracetamol exerts antipyretic and analgesic effects; amantadine hydrochloride exhibits anti-influenza activity; and other components help alleviate various discomforts associated with the common cold. This medication is also used to relieve symptoms—including fever, headache, sneezing, rhinorrhea (runny nose), cough, sputum production, and pharyngeal pain—caused by either bacterial or viral upper respiratory infections. Notably, amantadine possesses specific antiviral activity against influenza A virus, while other constituents provide anti-inflammatory and antiallergic effects.

Knowledge Extension: Adverse Effects of Compound Paracetamol and Amantadine Tablets

1. Persistent adverse reactions may include impaired concentration, dizziness, irritability, anorexia, and nervousness. Less common manifestations include headache, blurred vision, dryness of the mouth, nose, and throat, and constipation.

2. In some cases, hallucinations and psychiatric disturbances may occur, accompanied by slurred speech, involuntary eye movements, excessive central nervous system stimulation, or signs of toxicity. In elderly patients, this medication may cause urinary retention, syncope, orthostatic hypotension, and leukopenia.

3. Rarely, skin rashes, nausea, vomiting, diaphoresis (excessive sweating), abdominal pain, anorexia, and pallor may occur. Some patients may experience drowsiness and mild dizziness shortly after initiating therapy; these symptoms typically resolve upon discontinuation. Additionally, methemoglobinemia (with resultant cyanosis) may develop. Prolonged use or high-dose administration may impair hepatic and renal function.

The above provides an overview of Compound Paracetamol and Amantadine Tablets. We hope this information is helpful to you.