How is impetigo treated?

Pustulosis refers to a chronic, recurrent condition localized to the palms and soles. Clinically, it is characterized by periodic, sterile, small pustules developing on an erythematous background, accompanied by hyperkeratosis and scaling. It predominantly affects individuals aged 50–60 years, with a higher incidence in women than in men. So, how is pustulosis treated? The following addresses this question.

How Is Pustulosis Treated?

1. Oral Medications

Retinoids (e.g., acitretin) and immunosuppressants are commonly used oral agents. Frequently prescribed drugs include cyclosporine and methotrexate. Others include tetracycline or minocycline, colchicine, itraconazole, thiamphenicol, and tripterygium glycosides. However, these medications must be administered strictly under physician supervision to avoid disease exacerbation. Additionally, appropriate physical exercise and exposure to fresh air are recommended to enhance immune function and overall physical fitness—both of which play a positive role in the prevention and rehabilitation of palmoplantar pustulosis.

2. Topical Medications

Topical corticosteroids—particularly superpotent formulations—are applied to affected areas, often followed by occlusion therapy until lesion resolution or for up to four weeks. Tar-based ointments aid in pustule resolution and pruritus reduction; they also slow epidermal cell proliferation and promote desquamation, thereby preventing skin thickening. Other topical options include retinoid ointments, tacalcitol ointment, or calcipotriol ointment. As with all treatments, topical agents must be used only under medical guidance.

3. Phototherapy

Psoralen plus ultraviolet A (PUVA) therapy helps alleviate symptoms: patients first ingest psoralen, then receive targeted UVA irradiation to affected skin. Alternative phototherapies include excimer light or narrowband ultraviolet B (NB-UVB) irradiation directly applied to lesions, both of which improve clinical manifestations of pustulosis. Furthermore, when cleansing affected areas daily, use lukewarm water—not excessively hot or cold. Hot water may aggravate the condition, while very cold water may induce thermal imbalance, potentially triggering other health issues.

The above outlines current treatment approaches for pustulosis. We hope this information proves helpful.