Can "Xiao San Yang" be cured?
Oct 30, 2024
Source: Cainiu Health
Dr. Yang Ziqi
Introduction
In general, "small three positives" refers to a hepatitis B virus infection state in which hepatitis B surface antigen, hepatitis B e-antigen, and hepatitis B core antibody are all positive. Whether these three positive markers can be cured mainly depends on the severity of the disease. If the patient has a low viral load and mild condition, clinical cure is usually achievable; however, if the disease is severe, the likelihood of a cure is lower.
Generally, "small three positives" refers to a chronic hepatitis B virus infection state in which hepatitis B surface antigen, hepatitis B e-antigen, and hepatitis B core antibody are all positive. Whether these three markers can be cured mainly depends on the severity of the disease. If the patient has a low viral load and mild condition, clinical cure is usually achievable; however, if the condition is severe, the likelihood of a cure is much lower. The detailed analysis is as follows:
If the patient has a low viral load, normal liver function, and no significant liver inflammation or fibrosis, standardized antiviral therapy—such as using nucleoside analogues like entecavir tablets or tenofovir alafenamide fumarate tablets—can effectively suppress the virus, control the disease, and even achieve clinical cure, meaning long-term undetectable hepatitis B viral DNA.
Differences in individual health status, immune function, and viral replication levels mean that although some patients may achieve clinical cure, once hepatitis B virus invades the human body, it establishes residence within the nuclei of liver cells. Currently, there are no specific drugs capable of completely eliminating the hepatitis B virus. Moreover, if serious complications are present, treatment becomes more difficult. Therefore, patients typically require long-term antiviral therapy with regular monitoring of liver function and viral markers.
Patients can also promote liver function recovery, reduce liver inflammation, and enhance immunity through comprehensive measures such as dietary adjustments and lifestyle modifications.
