Will the NT value be elevated in fetuses with cleft lip and palate?

Nuchal translucency (NT) generally refers to the thickness of the transparent layer at the back of the fetal neck. However, the nuchal translucency measurement in fetuses with cleft lip and palate is not necessarily increased. The detailed explanation is as follows:

Nuchal translucency screening is typically performed between 11 and 14 weeks of gestation, measuring the thickness of fluid accumulation under the skin at the back of the fetal neck to assess the risk of chromosomal abnormalities or other structural malformations. Cleft lip and palate themselves do not directly lead to an increased nuchal translucency measurement. However, cleft lip and palate may sometimes be associated with other genetic disorders or syndromes, which could contribute to an increased NT value. For example, certain chromosomal abnormalities are linked to cleft lip and palate, and these same abnormalities are often accompanied by elevated nuchal translucency measurements.

If abnormal nuchal translucency values are detected during screening, further diagnostic evaluations should be conducted to promptly identify and manage any potential additional abnormalities. During pregnancy, it is important to maintain a balanced diet, adopt healthy lifestyle habits, and avoid harmful environmental exposures to support optimal fetal development.